The Waltham area is served by the Massachusetts Bay Transportation Authority, one of the nation’s most comprehensive mass transit systems. It lies between two major highways-Route 128/I-95, the inner loop, and Interstate 495, the outer loop, that encircles the region west of Boston. A number of east/west highways connect these and other western suburbs with Boston, its airport, and port facilities. Route 20, which crosses the state from east to west intersects with Route 128 in Waltham.
Logan International Airport is the closest airport to Waltham; it is about 20 minutes east
Waltham is accessible via Interstate 95 also called route 128, which connects to the Mass Pike (I-90). This is important if you are flying in or out of Logan airport because you are going to take I-90 West to get into Waltham and vice versa to get back into Boston. On I-90 there are two sets of toll plazas of $1.25 each, and rush hour can set you back 25-30 minutes between 4:30 and 6:30PM.
There are several trains from Boston daily. Take the Fitchburg line from North Station on the MBTA Commuter Rail to the Waltham or Brandeis/Roberts stop. The trains are a good way to get into Boston especially on the day of a sports game because they go directly to the Boston Garden. They are moderately priced.
Local MBTA buses 70 and 70A run from Central Square in Cambridge to Waltham. Several MBTA Express Buses (553, 554, 556, 558, 505) also serve Waltham. They originate several blocks from South Station in Boston and go to Waltham on weekdays only. Buses are usually reliable and inexpensive, but tend to get crowded around rush hour as well(4:30 to 6:30).
Driving around Waltham is not difficult and you can be just about anywhere in the city in 15 to 20 minutes. There are three main streets to Waltham: Main Street, Moody Street, Lexington Street. During rush hour(4:30 to 6:30) you will hit some traffic that may slow down your commute 10 to 15 minutes. Main Street is probably the worst during that time, and Moody Street can also be busy on a Friday or Saturday night. Parking is accessible with several public parking lots in high traffic areas, as well as on street parking.
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